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Year : 2018  |  Volume : 2  |  Issue : 1  |  Page : 12-14

An unusual cause of osteomalacia – A case report of phosphaturic mesenchymal tumor of the right hip bone

1 Department of Pathology, National University Hospital, Singapore 119074, Singapore
2 Department of Orthopaedic Surgery, National University Hospital, Singapore 119074, Singapore

Correspondence Address:
Bingcheng Wu
Department of Pathology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijcpc.ijcpc_10_18

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Phosphaturic mesenchymal tumor (PMT), while a rare entity, is nevertheless an important cause of oncogenic malacia/tumor-induced osteomalacia (TIO). We present a case of PMT. Our 47-year-old patient presented with unexplained osteomalacia refractory to medical therapy, associated with left subtrochanteric stress fracture. Further workup revealed the presence of a tumor in the left anterior inferior iliac spine, which was subsequently excised. Histopathology of the tumor showed the characteristic features of PMT, including grungy calcifications, osteoclast-type multinucleated giant cells, and bland round-to-spindled tumor cells. Following excision of the PMT, the patient's osteomalacia swiftly resolved. PMT is an important differential diagnosis in the context of oncogenic osteomalacia/TIO. As highlighted by our case report, PMT has fairly characteristic clinical and histopathologic features. However, given its rarity, an awareness of this entity is required for correct diagnosis and treatment.

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