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REVIEW ARTICLE
Year : 2019  |  Volume : 3  |  Issue : 1  |  Page : 7-11

Review on cytochrome C


Department of Pathology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Chennai, Tamil Nadu, India

Correspondence Address:
Anubhav Das
Department of Pathology, Saveetha Dental College, Saveetha Institute of Medical and Technical Science, Chennai, Tamil Nadu
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijcpc.ijcpc_8_19

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Cytochrome c (Cyt c) is an essential mitochondrial protein which takes part in the electron transport system and apoptosis. Cyt c also scavenges reactive oxygen species (ROS) and oxidizes cardiolipin during apoptosis. The recent finding that cyt c is phosphorylated in vivo for the important role of cyt c in the regulation of making life and death decisions. An apoptotic sequence of events takes place which involves changes in cyt c phosphorylation, increased ROS through increased mitochondrial membrane potentials, the oxidation of cardiolipin by cyt c, and its release from the mitochondria. Cyt c regulation in respiration and cellular death is discussed about human disease which includes neurodegenerative and cardiovascular diseases, cancer, and sepsis.


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