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ORIGINAL ARTICLE
Year : 2018  |  Volume : 2  |  Issue : 1  |  Page : 1-5

Demographic profile and clinicopathologic concordance of leprosy in the North-West part of Rajasthan, India: A 2 years prospective study


Department of Pathology, Government Medical College, Kota, Rajasthan, India

Correspondence Address:
Sanya Sharma
Department of Pathology, Government Medical College, Kota, Rajasthan
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijcpc.ijcpc_4_18

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Background: Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae principally affecting the skin and peripheral nerves. M. leprae is an obligate intracellular bacillus (0.3–1 μ wide and 1–8 μ long) that is acid-fast. Leprosy exhibits a spectrum of clinical characteristics that correlate with the histopathological changes and the immunological status of the individual. There is a range of varied clinicopathologic manifestations, and the diagnosis is made from adequate clinical information combined with histopathology. The aim of the study was to classify leprosy according to the Ridley–Jopling classification and perform the clinicopathological correlation. Materials and Methods: A prospective study was conducted on 184 cases of skin biopsies clinically diagnosed with leprosy, received in the Department of Pathology, Government Medical College, Kota from July 2015 to July 2017. Adequate clinical history was taken and biopsies were stained with hematoxylin and eosin and modified Fite Faraco stain. The Ridley and Jopling classification was followed in both clinical and histopathological diagnosis. Results: This study included 184 patients diagnosed clinically with leprosy. Skin biopsy revealed evidence of leprosy in 158 cases. A maximum number of patients clinically belonged to indeterminate leprosy which constituted 57 (30.9%) cases followed by borderline tuberculoid (BT) 41 cases (22.2%). On the contrary, histologically, although indeterminate leprosy was the most common with 51 cases (32.2%), the second most common was borderline lepromatous (BL) with 28 cases (17.7%) cases. Twenty-six cases of clinically diagnosed leprosy showed no features of leprosy histologically. The clinical and histopathological correlation was seen in 158 cases (85.3%the). The correlation was highest in BL (89.2%) followed by lepromatous and BT leprosy. Fite-Farraco stain was positive in 85 cases (53.7%). Conclusion: The classification of leprosy requires attention to the histopathological criteria and correlation with clinical information and bacteriological examination to facilitate accurate therapy.


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