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   Table of Contents - Current issue
Coverpage
July-December 2019
Volume 3 | Issue 2
Page Nos. 41-69

Online since Wednesday, December 11, 2019

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REVIEW ARTICLES  

Myeloid sarcoma p. 41
S Saivignesh, MP Brundha
DOI:10.4103/ijcpc.ijcpc_11_19  
Myeloid sarcoma is an extramedullary tumor of immature granulocytic cells. It is usually accompanied by acute myeloid leukemia, although in some rare cases, it may present in nonleukemic patients. It is a rare entity characterized by the occurrence of one or more tumor myeloid masses occurring at an extramedullary site. It may occur at any site, leading to very varied clinical presentations. However, the most common locations are soft tissues, bone, peritoneum, and lymph nodes. The aim of this review is to summarize about pathogenesis, diagnostic test, prognosis, and treatment of myeloid sarcoma.
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A review on ankylosing spondylitis p. 44
MG Visha, MP Brundha
DOI:10.4103/ijcpc.ijcpc_12_19  
Ankylosing spondylitis (AS) is a long-term inflammation of the joints of the spine which is complex, potentially debilitating disease that is insidious in onset, progressing to radiological sacroiliitis over a period of years. The pathogenesis of AS is poorly understood. However, immunomediated mechanisms involving human leukocyte antigen-B27, inflammatory cellular infiltrates, cytokines like tumor necrosis factor α and interleukin-10, and genetic and environmental factors are thought to have key roles. The presence of inflammatory back pain plus at least two other typical features of spondyloarthropathy such as enthesitis and uveitis is highly predictive of early AS. Nonsteroidal anti-inflammatory drugs (NSAIDs) effectively relieve inflammatory symptoms and are presently first line drug treatment. However, NSAIDs have an influence only on the symptomatic effect and has no effect on the disease. For symptoms unresponsive to NSAIDs, the second-line treatment includes corticosteroids and various disease modifying antirheumatic drugs are used.
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A review on wound healing p. 50
MG Visha, Monika Karunagaran
DOI:10.4103/ijcpc.ijcpc_13_19  
A wound is disruption of the anatomic structure and its useful continuity of residing tissue. Healing is the system of repair that follows damage to the skin and other soft tissues. Wound recovery is basically, a survival mechanism to restore shape and feature. The ability of a wound to heal depends partly on its intensity, as well as on the general fitness and dietary status of the man or woman. Clinically, wound may be categorized as acute or persistent primarily based at the timeliness of recuperation. The intense wound is a breakdown of the integrity of the gentle tissue envelope surrounding any part of the frame. Chronic wound is described, as ones wounds that fail to progress through orderly and timely sequence of restore or wounds that bypass through the restore system without restoring anatomic and useful effects. Although some additives of the recovery process have regenerative elements, pores and skin are the example of tissues in which the response to injury is predominantly certainly one of repair. Phases of wound healing are hemostasis, irritation, proliferation, epithelization, and maturation remodeling.
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ORIGINAL ARTICLE Top

Awareness of dengue fever among the parents of children coming to the dental outpatient department – A questionnaire study p. 60
PS Haritha, MP Brundha
DOI:10.4103/ijcpc.ijcpc_14_19  
Aim: The aim of this study is to establish the awareness of dengue fever among the parents of children coming to dental OutPatient department (OP). Objective: The objective was to design and complete a questionnaire to evaluate the awareness of dengue fever among the parents of children coming to dental OP. Background: The World Health Organization declares dengue to be endemic in South Asia. Dengue fever, also known as breakbone fever, is a mosquito-borne tropical disease caused by the dengue virus. Despite the magnitude of problem, no documented evidence exists on the awareness and preventive methods regarding dengue. This study is conducted to establish awareness, knowledge, and prevention regarding dengue fever among the parents of children coming to dental OP. Reason: To increase the awareness and thereby gaining the knowledge about the signs and symptoms of dengue fever for the early diagnosis and treatment. Materials and Methods: A cross-sectional study was performed among the parents of children coming to dental outpatient department. Around 80 parents were randomly selected for the questionnaire survey study. To assess awareness on dengue, the questionnaire was covered about knowledge on the signs and symptoms, mode of transmission, mosquito bite time, preventive measures, and source of their knowledge. Results and Conclusion: The study shows a low prevalence of sufficient knowledge in the population based on overall knowledge score on dengue. The isolated knowledge on signs and symptoms, prevention is adequate, with preventive measures mainly focused toward protection from mosquito bites.
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CASE REPORTS Top

Karyomegalic tubulointerstitial nephritis with primary focal segmental glomerulosclerosis in a young female: A rare form of steroid-nonresponsive nephrotic syndrome p. 64
Rajesh Kumar, Amit Kumar Singh, Gian Prakash, Rajan Duggal
DOI:10.4103/ijcpc.ijcpc_10_19  
Karyomegalic interstitial nephropathy (KIN) is a rare form of chronic tubulointerstitial nephritis initially described as a familial nephropathy in adults. We present a case of KIN with focal segmental glomerulosclerosis in a 15-year-old young female who became late nonresponder and resistant to steroid therapy. To our knowledge, only one case has been reported in literature.
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DNA methylation subtype and H3K27Me3 status of a case of clear-cell meningioma of the lateral sphenoid wing p. 67
Aaron Song Chuan Foo, Bingcheng Wu, Felix Sahm, Shilin Wang, Lwin Sein
DOI:10.4103/ijcpc.ijcpc_15_19  
We report a case of lateral sphenoid wing clear-cell meningioma in a 68-year-old male. Clear-cell meningiomas account for 0.2%–0.8% of meningiomas and are notorious for their aggressive clinical behavior. To our surprise, DNA methylation profiling and H3K27Me3 testing suggested an indolent meningioma subtype in our patient's case. This case illustrates discrepancies between histopathological and molecular-based classification systems and highlights the importance of considering the molecular profile of tumors during prognostication.
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