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  Indian J Med Microbiol
 

Figure 3: (a) There is an area of fibroadenoma with lactating change (upper half of field) and an area of lactating adenoma (lower half of field). It is unclear if lactating adenoma represents a specific neoplasm or if it is simply a result of hormone-induced changes occurring within a pre-existing fibroadenoma/tubular adenoma during pregnancy (H and E, ×20). (b) A close-up view of the lactating adenoma demonstrates lobular expansion with closely packed acini, but otherwise, there is overall preservation of the lobular architecture. The lumina are generally open and may contain secretions (not seen in this figure). The epithelial cells lining the acini demonstrate enlarged hyperchromatic and hobnailed nuclei, as well as ample clear vacuolated cytoplasm. These changes correspond to the fine needle aspiration cytology findings seen in Figure 2. A terminal duct lobular unit without lactational change is present in the upper right field for comparison (H and E, ×100)

Figure 3: (a) There is an area of fibroadenoma with lactating change (upper half of field) and an area of lactating adenoma (lower half of field). It is unclear if lactating adenoma represents a specific neoplasm or if it is simply a result of hormone-induced changes occurring within a pre-existing fibroadenoma/tubular adenoma during pregnancy (H and E, ×20). (b) A close-up view of the lactating adenoma demonstrates lobular expansion with closely packed acini, but otherwise, there is overall preservation of the lobular architecture. The lumina are generally open and may contain secretions (not seen in this figure). The epithelial cells lining the acini demonstrate enlarged hyperchromatic and hobnailed nuclei, as well as ample clear vacuolated cytoplasm. These changes correspond to the fine needle aspiration cytology findings seen in Figure 2. A terminal duct lobular unit without lactational change is present in the upper right field for comparison (H and E, ×100)