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Year : 2019  |  Volume : 3  |  Issue : 2  |  Page : 67-69

DNA methylation subtype and H3K27Me3 status of a case of clear-cell meningioma of the lateral sphenoid wing

1 Department of Surgery, Division of Neurosurgery, National University Hospital, Singapore
2 Department of Pathology, National University Hospital, Singapore
3 Department of Neuropathology, Institute of Pathology, University Heidelberg, Heidelberg, Germany

Correspondence Address:
Bingcheng Wu
Department of Pathology, National University Hospital
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijcpc.ijcpc_15_19

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We report a case of lateral sphenoid wing clear-cell meningioma in a 68-year-old male. Clear-cell meningiomas account for 0.2%–0.8% of meningiomas and are notorious for their aggressive clinical behavior. To our surprise, DNA methylation profiling and H3K27Me3 testing suggested an indolent meningioma subtype in our patient's case. This case illustrates discrepancies between histopathological and molecular-based classification systems and highlights the importance of considering the molecular profile of tumors during prognostication.

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