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   Table of Contents - Current issue
January-June 2020
Volume 4 | Issue 1
Page Nos. 1-22

Online since Tuesday, July 28, 2020

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Clinicopathological correlation of radical prostatectomy specimens p. 1
Neeraj Dhameja, Sandip Kumar, Sameer Trivedi, US Dwivedi
Introduction: Prostate cancer is the most common cancer in male, and histopathological examination of the prostatic tissue plays a very important role in diagnosis, prognosis, and management of patients with prostatic carcinoma. Objective: To study the histopathological features of the radical prostatectomy specimens which decide prognosis and further management of patients with prostatic carcinoma and correlation with trucut biopsy. Materials and Methods: Fourteen radical prostatectomy specimens were evaluated which were grossed by standard techniques, and histopathological parameters were evaluated on hematoxylin and eosin-stained sections. Results: Histopathologically acinar carcinoma is the most common type of prostatic carcinoma though there may be other types also. In this study only acinar carcinoma was found in all cases. Gleason pattern 3 and 4 were the predominant primary and secondary patterns respectively. Previous trucut biopsies result were available in 5 cases and in 4 cases grades were same in trucut biopsies and radical prostatectomy specimens however, in one case Gleason score in radical prostatectomy specimen was upgraded. Detailed histopathological examination of radical prostatectomy specimens according to prescribed guidelines is essential so that further management can be decided. The number of cases in this study are less more cases should be evaluated. Conclusions: Detailed histopathological examination of radical prostatectomy specimens including extent into surrounding structures helps in prognosis and further management of patients with prostatic carcinoma.
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Lupus miliaris disseminatus faciei: A rare case report p. 7
Anupama Manohar Prasad, Aneeha Ramesh Babu, K Nagaswetha
Lupus miliaris disseminatus faciei (LMDF), initially thought to be a tuberculid, is an uncommon independent clinicopathological entity characterized by asymptomatic erythematous papules over the face, usually encountered in young individuals and rarely in the extremes of age group. It was initially thought to be a tuberculid due to similar histopathological features between the two entities. LMDF has a spontaneously resolving course; however, due to its ability to cosmetically debilitate an individual, patients often seek a dermatologist's opinion. Various treatment options, such as oral tetracyclines, steroids, and retinoids, have been tried with varying results. Around 200 cases have been reported till date, and further studies are needed to understand the etiopathogenesis and management of this distinct dermatosis. We report a case of LMDF in a young lady who was started on oral minocycline and topical tacrolimus but was lost to follow-up. We hereby report this case for its rare occurrence. The present paper highlights the clinical importance of LMDF mimicking granulomatous facial dermatitis and the need for further laboratory investigations to rule out tuberculosis. This report reviews the available literature and presents a patient with LMDF. Biopsy done on one of the lesions over face showed epidermal atrophy, dermal perivascular and periadnexal inflammatory infiltrate, focal granulomatous inflammation with multinucleated giant cells, with the special stain for acid-fast bacilli being negative. These findings suggested LMDF. LMDF is a distinct granulomatous inflammatory dermatosis not associated with cutaneous tuberculosis.
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Hepatosplenic T-cell lymphoma: A clinical diagnostic challenge p. 10
Nalini Bansal, Ankush Pawar, Pankaj Puri, Subrat Acharya
Hepatosplenic T-cell lymphoma (HSTCL) is a rare variant of T-cell lymphoma and comprises less than 5% of all peripheral T-cell lymphomas. These lymphomas have an aggressive course and dismal prognosis. We report a case of a 28-year-old male who presented with repeated episodes of fever and abdominal pain. Ultrasonography revealed hepatosplenomegaly. Liver biopsy performed showed sinusoidal lymphoid cell infiltration of the T-cell immunophenotype with aberrant antigen loss. The case was finally diagnosed as HSTCL.
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A rare histomorphological coexistence of clear cell carcinoma and mucinous cystadenoma of the ovary in a young female with brief review of literature p. 13
Syeda Firdos Jamil, Neha Sethi, Anjali Sharma, Kirti Pandya
Concomitant clear cell carcinoma of the ovary and mucinous cystadenoma of the ovary in the absence of endometriosis are rare entities with very few cases cited in the literature. They pose diagnostic challenge as the differential diagnosis spans from germ cell tumor, sex cord stromal tumor, and other surface epithelial tumors. The various types of tumors have different prognosis and varied treatment protocols. The presence of advanced stage and paraneoplastic syndrome has been associated with poor prognosis. We present a case of a 35-year-old female who presented with complaints of abdominal distension and discomfort for the past 2 months. The patient underwent right-sided oophorectomy in 2016 which was diagnosed as mucinous cystadenoma. The radiological evaluation revealed an enlarged left ovary with solid cystic areas. CA-125 was marginally raised. Oophorectomy with hysterectomy was done. Histopathology showed an unusual combination of clear cell carcinoma with mucinous cystadenoma. There was no endometriosis although omental metastasis was noted. The finding was confirmed on immunohistochemistry. The occurrence of clear cell carcinoma with mucinous cystadenoma in the absence of endometriosis is extremely uncommon with very few literature studies available.
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Primary ovarian leiomyoma: A rare tumor with a diagnostic dilemma p. 17
K Sajitha, HL Kishan Prasad, Gaurvi Piplani, Neetha Nandan, Michelle Mathias, Jayaprakash K Shetty
Primary ovarian leiomyomas are rare tumors accounting for 0.5%–1% of all ovarian tumors. They are seen commonly in the reproductive age group. Morphologically, they resemble leiomyomas occurring at other sites. The definitive preoperative diagnosis is difficult due to the lack of characteristic radiological features. Here, we describe a case of ovarian leiomyoma, which has posed a diagnostic and therapeutic challenge. The final diagnosis was confirmed by immunohistochemistry.
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Oral lymphangioma p. 20
Devika S Pillai, Renita Lorina Castelino, Subhas G Babu, Sajad Ahmad Buch
Lymphangioma is a benign hamartomatous neoplasm of the lymphatic vessels. Head-and-neck lymphangiomas are rare but when it affects, tongue is the most common site. These tumors usually manifest within the 1st year of life. When it affects the tongue, there may be either a localized or diffused growth that can enlarge to cause macroglossia. The complications associated with lymphangiomas include occlusal disturbances, disturbances in speech, and poor oral hygiene. Here, we present a case of lymphangioma of the tongue in a 26-year-old male patient who was diagnosed following a routine dental examination.
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